Features
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Ultra PurePep Pathway “inside”
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The proprietary ultra PurePep Pathway is enhanced with a dedicated microfluidic matrix valve block pathway for each reaction vessel resulting in pure peptides. Nitrogen and vacuum move all fluids through the system, the membranes are resistant to harsh chemicals, there is zero dead volumes, no cross-contamination, and best-in-class performance that lasts for years. Other systems use off-the-shelf valves that leak or corrode, result in cross-contamination, and quickly fail when exposed to harsh peptide synthesis chemicals. With the ultra PurePep Pathway inside Symphony® X, all fluid deliveries are verified via optical sensors and you have reliable peptide purity every time.
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Fully independent channels
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Symphony X is the world’s first peptide synthesizer with fully independent channels. This means you can run different sequences, scales and protocols on multiple reactors all at the same time. Start, Stop or Pause reactors whenever you wish! It’s like having 24 synthesizers in one.
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Infrared (IR) heating
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Efficient heating, reaching set temperature in minimal time. It is also fully-compatible with vortex mixing, so you can be sure you have an even temperature profile. Other heating systems use nitrogen mixing, which may result in hot and cold spots and effect the consistency of your chemistry.
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Real-time UV monitoring
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Minimize trial-and-error when synthesizing difficult peptides using the Intellisynth® real-time UV monitoring on the Symphony X instrument. What makes our UV monitoring different? Other systems just monitor the waste stream. We monitor your reaction solution while it’s mixing – that’s why we’re the only ones who can control the deprotection reaction times, not just the number of repetitions. Real-time UV monitoring ensures that reactions are completed efficiently and no excess reagent is wasted.
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Preactivation
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Now you can preactivate on multiple reactors in parallel. Perfect for sterically hindered amino acid additions! Optimize your DIC/HOBt chemistry on Symphony X and go straight to scale-up.
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Special reagent additions
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At last! Add expensive special reagents to any reactor without priming or wasting a drop using Single-Shot™ deliveries! Save money with no manual intervention required! Symphony X comes with up to 40 amino acid positions to accommodate any chemistry.
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Automated cleavage
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Symphony X includes the ability to do automated, fully customizable cleavage without the need for an additional module. Choose to cleave immediately (Fmoc only), at the end of a synthesis, or at a specified date and time. Cleaved peptides are collected in convenient 50 mL centrifuge vials. All Protein Technologies’ synthesizers are built with robust TFA-resistant materials, so you can cleave for years on the instruments without worry. Not interested in cleavage? You have the flexibility to use the Symphony X collection positions as additional amino acid positions.
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Specifications
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Number of reaction vessels
Synthesis scale range Reaction vessel volume Number of solvent positions/sizes Number of amino acid positions Chemistries supported Activation Throughput Fluid measurement technique Fluid transfer method Agitation method Cleavage Waste container Control interface Reporting Power Dimensions (W x D x H) Weight OPTIONAL - Heating OPTIONAL - UV Monitoring OPTIONAL - Software |
24 (12 with pre-activation option), no resin loader required
0.005 – 24 mmol (up to ~2 g of resin per RV) Plastic, disposable:10 mL, 45 mL, Borosilicate glass: 10 mL, 40 mL 1 primary solvent position, 20 L capacity 7 user-defined solvent positions, 0.5 L - 4 L capacities Up to 40 amino acid positions 10 mL, 120 mL and 400 mL bottles Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA In situ HBTU, HATU, HCTU, TBTU, PyBOP, PyOxim, DIC/OxymaPure, DIC/HOBt, DIC/Oxyma-B and others User defined Fixed loop measurement with optical sensors Positive pressure with nitrogen; top down delivery Nitrogen bubbling and/or vortex mixing can be adjustable and programmable Automated on-board cleavage, separate fluid path and vent One 20 L container with over-flow sensor Proprietary Symphony X control software, internal CPU and touchscreen monitor included Real-time log of each instrument function, print to file or printer. Printable .pdf file for each method created. 115 V/60 Hz or 230 V/50 Hz 114 cm x 74 cm x 168 cm (45” x 29” x 66”) Approximately 250 kg (550 lbs.) Infrared (IR) heating (Cat#: SYMX-IR-OPT) Intellisynth Real-time UV Monitoring and feedback control system and software (Cat#: SYMX UV OPT) E-mail-Text Message Status Reporting (Cat#: SYMX-TXT-EML-RP) |