Home > Peptide Synthesizer > SonataXT
PurePep Pathway “Inside”
The design power of the proprietary PurePep Pathway (valve block system) results in zero dead volumes, no cross-contamination, and worry-free performance that lasts for years. Other systems use off-the-shelf valves that leak, cross-contaminate, and quickly fail when exposed to harsh peptide synthesis chemicals. With the trusted PurePep Pathway inside Sonata/Sonata XT, you have reliable peptide purity every time.
Multiple mixing modes
Sonata has chemically inert, optimized channels allowing high solution transfer rates (> 400 mL/min) of any solvent. All reactions occur in an inert environment to minimize side reactions. Multiple mixing modes including sparging, recirculation and mechanical agitation which can be combined to maximize reaction efficiency. Several fluid-filling methods can be selected to optimize performance.
Solvent and reagent positions
Seven solvent ports and twenty reagent ports allow easy customization for any synthesis protocol. Two volumetric vessels allow precise aliquots of all solvents/reagents to be delivered. To minimize disposal costs, two waste ports allow waste streams to be separated. A collection port can be implemented for cleavage product or valuable reagent recovery for maximum versatility.
Versatile, easy to use Windows®-based software allows the experienced chemist or novice operator complete control of all aspects of synthesis. Complete documentation of all operations occurs once synthesis is initiated.
Number of reaction vessels
Synthesis scale range
Reaction vessel volume
Number of solvent positions/sizes
Number of amino acid positions
Fluid measurement technique
Fluid transfer method
0.05 mmol to 100 mmol (200 mmol on Sonata XT)
Glass: 200 mL, 500 mL, 1.2 L, 2 L, 3.2 L, 4.2 L
Custom sizes available
1 primary solvent, 1 L – 200 L capacity
6 user-defined solvent positions, 0.5 L - 4 L capacities
20 amino acid / reagent positions, 250 mL capacity (500 mL or 1 L on Sonata XT)
Fmoc, t-Boc, organic, peptoid, combinatorial, others
HBTU, HATU, HCTU, TBTU, PyBOP, DIC, others
Fixed volumetric vessels with optical sensors, 10, 25, 50, 75, 100 mL sizes, other optional
Positive pressure with nitrogen for solvents and reagents
Dedicated pump for primary solvent
Nitrogen bubbling (adjustable), variable vortexing, recirculation
-Alone or in combination
Automatic, programmable (for Fmoc chemistry only)
20 L container with overflow sensor
200 L option available
Proprietary Sonata control software. The system is used in a GMP environment.
Menu-driven. Stand-alone computer, flat panel monitor and printer included.
Real-time log of each instrument function. Print to file, screen or printer.
115 V/60 Hz or 230 V/50 Hz
35" x 23" x 63.5" (89 cm x 58 cm x 161 cm)
Approximately 400 lbs. (182 kg)
One year, parts and labor