Raman RXN2 Hybrid
Small spot and wide area Raman sampling
The RAMANRXN2™ HYBRID analyzer is the first Raman analyzer to feature both traditional small spot Raman sampling and PhAT-based wide area Raman sampling. Small spot immersion sampling remains the preferred approach for liquid-phase analysis of reaction mixtures while the added capability of PhAT-based wide area Raman sampling allows Raman analysis to be extended into the solid sampling arena eliminating sub-sampling concerns. The RAMANRXN2™ HYBRID analyzer uses PhAT technology to allow quantitative monitoring and control of solid formulations during unit operations.
The RAMANRXN2™ HYBRID fiber-coupled Raman analyzer serves the needs of the analytical Raman market, process analytics, chemical, and polymer markets, as well as the pharmaceutical and biotech markets. When combined with the latest compliant version of the iC Raman™ data acquisition software, the RAMANRXN2™ HYBRID analyzer meets the needs of both GLP and GMP governed areas within the pharmaceutical industry for both PAT and QbD applications.
The RAMANRXN2™ HYBRID analyzer provides the capability of several different Raman analyzers in a single system. Equally capable of being a transportable raw materials identification analyzer, a bench-top analyzer for methods development in the lab, reaction monitoring in the pilot plant, process control development in a manufacturing environment, or a dedicated quality control analyzer.
At the heart of the RAMANRXN2™ HYBRID analyzer is a unique analyzer self monitoring system to ensure the validity of each analysis. The analyzer is capable of self-calibration in extreme environments and utilizes self-diagnostics and spectral correction methods when system calibration is unnecessary. The analyzer's precision is essential for robust chemometric analyses and calibration transfer between analyzers.
Versatility was a key goal when developing the feature set for the RAMANRXN2™ HYBRID analyzer. Millimeter to micron sampling versatility is accomplished by coupling the RAMANRXN2™ HYBRID analyzer with either the MR Probe or the PhAT probe heads for non-contact or direct insertion sampling. Standard on all RAMANRXN2C™ models and available as an option for the RAMANRXN2™ HYBRID analyzer, is an ergonomic trolley including built-in probe and optic storage, a routine-analysis sample compartment, fiber storage, and the analyzer control system.
For in situ reaction analysis the RAMANRXN2™ HYBRID analyzer is capable of using either the MR Probe for laboratory measurements or the Pilot-E process probe for pilot-scale measurements from 100 to 10,000 gallons.
For formulations development, sampling versatility is accomplished using a fiber-optically coupled PhAT probe heads. Fiber-optic flexibility provides for simple flexible installation to various unit operations and a variety of manufacturing equipment. Both insertion and non-contact sampling options are available for the PhAT probe heads to enhance sampling flexibility. A special probe interface is available for in situ tablet coating applications.
The RAMANRXN2™ HYBRID fiber-coupled Raman analyzer serves the needs of the analytical Raman market, process analytics, chemical, and polymer markets, as well as the pharmaceutical and biotech markets. When combined with the latest compliant version of the iC Raman™ data acquisition software, the RAMANRXN2™ HYBRID analyzer meets the needs of both GLP and GMP governed areas within the pharmaceutical industry for both PAT and QbD applications.
The RAMANRXN2™ HYBRID analyzer provides the capability of several different Raman analyzers in a single system. Equally capable of being a transportable raw materials identification analyzer, a bench-top analyzer for methods development in the lab, reaction monitoring in the pilot plant, process control development in a manufacturing environment, or a dedicated quality control analyzer.
At the heart of the RAMANRXN2™ HYBRID analyzer is a unique analyzer self monitoring system to ensure the validity of each analysis. The analyzer is capable of self-calibration in extreme environments and utilizes self-diagnostics and spectral correction methods when system calibration is unnecessary. The analyzer's precision is essential for robust chemometric analyses and calibration transfer between analyzers.
Versatility was a key goal when developing the feature set for the RAMANRXN2™ HYBRID analyzer. Millimeter to micron sampling versatility is accomplished by coupling the RAMANRXN2™ HYBRID analyzer with either the MR Probe or the PhAT probe heads for non-contact or direct insertion sampling. Standard on all RAMANRXN2C™ models and available as an option for the RAMANRXN2™ HYBRID analyzer, is an ergonomic trolley including built-in probe and optic storage, a routine-analysis sample compartment, fiber storage, and the analyzer control system.
For in situ reaction analysis the RAMANRXN2™ HYBRID analyzer is capable of using either the MR Probe for laboratory measurements or the Pilot-E process probe for pilot-scale measurements from 100 to 10,000 gallons.
For formulations development, sampling versatility is accomplished using a fiber-optically coupled PhAT probe heads. Fiber-optic flexibility provides for simple flexible installation to various unit operations and a variety of manufacturing equipment. Both insertion and non-contact sampling options are available for the PhAT probe heads to enhance sampling flexibility. A special probe interface is available for in situ tablet coating applications.
ApplicationsMR Probe-based Reaction Analysis
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PhAT-based Formulation Studies
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Analyzer Features
Options
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iC Raman™ 4.1
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Precision, Stability, Methods Transfer
- Better than 0.1 cm-1 long term precision
- Cal-Check™ – system verification
- Auto-Cal™ for analyzer calibration
- NIST-traceable intensity calibration protocol – calibration from the sample to the detector
- Demonstrated calibration transfer: Plant-to-plant, country-to-country
