Productivity inside PurePep Chorus
From start to finish, PurePep Chorus is designed for an efficient workflow. This includes the use of a completely new software platform designed with the productivity of the user in mind:
Intuitive menu guided workflow
PurePep Pathway “inside”
The design power of the proprietary PurePep Pathway (valve block system) results in zero dead volumes, no cross-contamination, and worry-free performance that lasts for years. No cross-contamination, and no failure due to harsh peptide synthesis chemicals. With the trusted PurePep Pathway inside PurePep Chorus, you have reliable peptide purity every time.
Configurable 2, 4 or 6 RVs
Choose between 2, 4 or 6 reaction vessels depending on your throughput needs. This modular design enables in-lab upgrades aligned with the growing needs of peptide researchers.
Controlled induction heating and Oscillation mixing
You decide how many reaction vessels include induction heating capabilities. The and Oscillation mixing patent-pending technology takes just seconds to reach temperature, does not result in temperature overshooting and enables controlled heating between 25°C and 90°C. The technology is fully-compatible with oscillation mixing, which ensures even temperature profiles, homogenous chemistry, and high yields. Combined with the adjustable nitrogen mixing that is also included on each reaction vessel , PurePep Chorus allows complete control of reaction parameters for precise and reproducible peptide synthesis.
Real-time UV monitoring
Select how many reaction vessels to configure with UV monitoring. Minimize trial- and-error when synthesizing peptides using the IntellisynthTM real- time UV monitoring on PurePep Chorus. What makes this UV monitoring different? Monitoring your reaction solution while it’s mixing, resulting in control of the deprotection reaction times, not just the number of repetitions. When using Single- ShotTM amino acid delivery, real-time UV monitoring ensures that reactions are completed efficiently and no excess reagent is wasted.
PurePep Chorus has the ability to do automated, fully customizable cleavage without the need for an additional module. Choose to cleave immediately (Fmoc only), at the end of a synthesis, or at a specified date and time. Cleaved peptides are collected in convenient 50 mL centrifuge vials. All Gyros Protein Technologies’ synthesizers are built with robust TFA-resistant materials, so you can cleave for years on the instruments without worry. Not interested in cleavage? You have the flexibility to use the collection positions as additional amino acid positions.
With the ability to run three preactivation reactions in parallel, PurePep Chorus is ideal for sterically hindered amino acid additions. Additionally, DIC/HOBt chemistry can be optimized and go straight to scale-up.
The icon-driven software simplifies the chemist’s workflow and accelerates set up of peptide synthesis methods. Pre-programmed methods may be used as is, or as a template for customized methods and sequences can be easily imported to avoid errors. Increase your productivity and program new syntheses while others are already running. The software is designed for 21 CFR part 11 compliance.
Number of reaction vessels
Synthesis scale range
Reaction vessel volume
Number of solvent positions / sizes
Number of amino acid positions
Fluid transfer method
Dimensions (W x D x H)
2, 4, 6 configurable with in-lab upgrades
0.005 - 1.0 mmol per reaction vessel (6.0 mmol total for a 6 RV system)
Controlled induction heating, configurable to the number of RVs
Intellisynth Real-time UV Monitoring and feedback control system, configurable to the number of RVs
Nitrogen bubbling - adjustable, and/or optional
oscillating shaker mixing
Plastic, disposable: 10 mL, 45 mL
Borosilicate glass: 10 mL, 25 mL, 40 mL
8 solvents (1 to 4 L each standard, larger vessels available)
27 amino acid bottles or Single-Shots plus six Single-Shot only positions for specialty reagents.
10 mL (for standard or Single-Shot delivery for specialty reagents), 50 mL (Single-Shot only positions), 120 mL, and 400 mL sizes.
Pre-packaged and empty bottles available.
Fmoc, t-Boc, organic, peptoid, combinatorial, branched, PNA
in situ and pre-activation
Positive pressure with nitrogen
Automated on-board cleavage, separate fluid path and vent
(1) 20 L D.O.T rated container with over-flow sensor in cap
Proprietary PurePep Chorus control software, internal CPU, tablet (wireless connection)
Real-time log of each instrument function, print to file or printer. Includes e-mail notifications to send an email to a computer or cell phone at a specified program step, at the beginning of each cycle, or if an error occurs.
40 pre-packed AA bottles (20 natural amino acids; 5 mmol and 20 mmol scales), Reaction Vessels (disposable RVs, 30 pack of 10 mL and 30 pack of 45 mL RVs), Rink Amide Resin (0.1 mmol scale), Fmoc-L-Gly Wang Resin (0.1 mmol scale), HCTU (100 g), Activator Sample kit (5 g each of K-Oxyma, PyOxim, OxymaPure and HDMA). Shipments to the USA also include 20% Piperidine/DMF and 0.4M N-Methylmorpholine/DMF (0.9 L each) reagents.
100-230VAC , 50/60Hz
87.1 cm x 72.1 cm x 72.4 cm (34.3” x 28.4” x 28.5”)
90.7 kg (200 lbs)
One year, parts and labor.
Installation qualification and operation qualification (IQ/OQ) support services verify and document that your instrument is supplied, installed, and operating according to GPT specifications, and may be required for operating under cGMP conditions. GPT-certified field service engineers inspect critical components, ensure that your systems function properly and reproducibly during automated synthesis operations, and provide documentation to help you meet regulatory requirements.