NanoRam
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The NanoRam® is the state-of-the-art compact handheld Raman analyzer designed for use by non-specialists, and easily operates single-handedly. It allows rapid development of libraries and methods for material identification and verification within cGMP compliant facilities, whether in the lab, the warehouse, the loading dock or the field.
Raman spectroscopy is an approved method by US Pharmacopeia, European Pharmacopeia, Pharmacopeia of the People’s Republic of China and is a well-recognized method for compliance with the PICS GMP guide to provide 100% assurance of the identity of each container of starting material. The NanoRam is fully compliant with all governing regulations including 21 CFR Part 11 and Part 1040.10. B&W Tek offers a wide variety of services including assistance with method and/or new library development and other services such as support with IQ/OQ/PQ validation. Intuitive Software – a user-friendly tool for both technical & non-technical users to make their job easier Versatility – measure a variety of samples in a variety of environments and packaging with just one unit Data Reproducibility – superior hardware ensures that results are consistent and reliable Performance – robust multivariate algorithms guarantee accuracy when testing and identifying materials Feature
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Specifications
SoftwareState-of-the-art Identification Software
The NanoRam comes standard with B&W Tek’s proprietary Nanoram OS installed within the unit, which allows for identification and verification, library and method development, and data storage/ transfer. The Nanoram ID is designed for use on PCs and the iSpec Mobile is for tablet computers (such as the iPad) for data and methods management, allowing customers to export data and generate reports. The Nanoram ID and the Nanoram OS software packages are 21CFR part 11 compliant with available IQ/OQ validation documentation for pharmaceutical customers. |
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Additionally, the NanoRam provides Wi-Fi synchronization capabilities with network terminals in order to optimize time and resources. Nanoram OS is also capable of real time data and report transfers to ERP/QMS systems in order to centralize information (such as libraries, method development and final reports) in general servers. Unlike any other handheld instrument, the NanoRam is capable of transferring libraries from one unit to another utilizing proprietary algorithms to assure compatibility.
For customers that require a more detailed personalization of the user interface or method development, B&W Tek offers an optional software development kit (SDK) for software customization. |
Mixture Analysis
• Upon receiving “No Match” result or matched HQI is lower than 93, user can press the Mixture button on the result page and
• The system will run mixture analysis on the given signature to determine possible substance components.
• The laser does not emit during the mixture analysis. A mixture result will follow.
• Upon receiving “No Match” result or matched HQI is lower than 93, user can press the Mixture button on the result page and
• The system will run mixture analysis on the given signature to determine possible substance components.
• The laser does not emit during the mixture analysis. A mixture result will follow.
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Sampling Accessories
Easy Transition Between Sample Types
The NanoRam includes a variety of sampling accessories to assist you in the measurement of various materials in the form of liquids, gels, powders, or solids under both lab and demanding environmental conditions. The NanoRam is designed to facilitate fast and convenient transitions between sample adaptors.
The NanoRam comes standard with the point and shoot, vial holder, and bottle adaptor accessories. Additionally, right angle, tablet holder, and immersion shaft accessories are available to facilitate even more sampling situations. These accessories allow you to measure through plastic and glass containers, take in situ measurements of liquids and powders, and measure larger containers only accessible from the top. More details about individual accessories are available upon request
The NanoRam includes a variety of sampling accessories to assist you in the measurement of various materials in the form of liquids, gels, powders, or solids under both lab and demanding environmental conditions. The NanoRam is designed to facilitate fast and convenient transitions between sample adaptors.
The NanoRam comes standard with the point and shoot, vial holder, and bottle adaptor accessories. Additionally, right angle, tablet holder, and immersion shaft accessories are available to facilitate even more sampling situations. These accessories allow you to measure through plastic and glass containers, take in situ measurements of liquids and powders, and measure larger containers only accessible from the top. More details about individual accessories are available upon request
Integrated Computer
State-of-the-art Touch Screen
The NanoRam offers unprecedented calculation power for handheld devices, employing a fast processor optimized to operate under B&W Tek’s proprietary Nanoram OS. Within seconds, it is able to process data, manage libraries of any size, and accurately identify the materials analyzed with a new level of quality from portable devices. It is designed with the capability to run almost any calculation required in day- to-day operations, without the need to download data for post-processing.
The NanoRam offers unprecedented calculation power for handheld devices, employing a fast processor optimized to operate under B&W Tek’s proprietary Nanoram OS. Within seconds, it is able to process data, manage libraries of any size, and accurately identify the materials analyzed with a new level of quality from portable devices. It is designed with the capability to run almost any calculation required in day- to-day operations, without the need to download data for post-processing.
Spectrometer
Optimized for Raman Spectroscopy
The standard configuration for the spectrometer in the NanoRam is for a 785nm laser excitation wavelength. The Crossed Czerny-Turner optical design achieves a spectral resolution of 9cm-1, while simultaneously keeping the footprint of our NanoRam small. This brings an enormous advantage for field Raman applications.
The standard configuration for the spectrometer in the NanoRam is for a 785nm laser excitation wavelength. The Crossed Czerny-Turner optical design achieves a spectral resolution of 9cm-1, while simultaneously keeping the footprint of our NanoRam small. This brings an enormous advantage for field Raman applications.
Detector
Cooled Detector for Low-Light Level Detection
Cooling an array detector with a built-in thermoelectric cooler (TEC) is an effective way to reduce dark current and noise to enhance the dynamic range and detection limit. The graphs below show the dark current and noise for an uncooled versus cooled CCD detector at an integration time of 30 seconds. Operating at room temperature, the dark current nearly saturates the uncooled CCD. When the CCD is cooled to 18oC, the dark current is reduced by two times. This allows the spectrometer to operate at long integration times and detect weak optical signals.
Cooling an array detector with a built-in thermoelectric cooler (TEC) is an effective way to reduce dark current and noise to enhance the dynamic range and detection limit. The graphs below show the dark current and noise for an uncooled versus cooled CCD detector at an integration time of 30 seconds. Operating at room temperature, the dark current nearly saturates the uncooled CCD. When the CCD is cooled to 18oC, the dark current is reduced by two times. This allows the spectrometer to operate at long integration times and detect weak optical signals.
Laser
Creating Raman Scatter
In Raman spectroscopy, it is essential to utilize a clean, narrow bandwidth laser due to the fact that the quality of the Raman peaks are directly affected by the sharpness and stability of the delivered light source. The NanoRam series spectrometer systems feature a patented CleanLaze technology with a linewidth < 0.3nm when equipped with our 785nm laser. This technology results in the correct center wavelength and avoids the phenomenon of “mode hopping.” In addition, the laser output power can be adjusted in the software from 10 - 100%, allowing you to maximize the signal-to-noise ratio and minimize measurement time.
Laser lifetime of 10,000 hours ensures quality data for years to come!
In Raman spectroscopy, it is essential to utilize a clean, narrow bandwidth laser due to the fact that the quality of the Raman peaks are directly affected by the sharpness and stability of the delivered light source. The NanoRam series spectrometer systems feature a patented CleanLaze technology with a linewidth < 0.3nm when equipped with our 785nm laser. This technology results in the correct center wavelength and avoids the phenomenon of “mode hopping.” In addition, the laser output power can be adjusted in the software from 10 - 100%, allowing you to maximize the signal-to-noise ratio and minimize measurement time.
Laser lifetime of 10,000 hours ensures quality data for years to come!