11 AM EST Wed 21, April 2021 (한국시간 2021년 4월22일 목요일 오전 0시)

Peptide-based therapeutics are increasingly being seen as the future for many drug development programs, and these compounds can be found in many clinical therapeutic areas such as cancer vaccines, personalized medicines, and treatments for metabolic and cardiovascular diseases. These ground-breaking drug discoveries usually begin with the solid phase peptide synthesis (SPPS) of a target sequence. With the increasing chemical complexity of these peptides how can you maximize the likelihood of success when developing a protocol to automate synthesis for a new peptide sequence? How can the risk of side-reactions be minimized? And what challenges face the chemist when moving to manufacture?
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This webinar will cover the main areas of SPPS theory and synthesis design, focusing on first principles such as sequence analysis and synthetic methodology. There will also be a focus on side reactions that occur during SPPS and what strategies can be employed to reduce or eliminate these from occurring. We also discuss features of peptide synthesizers that are critical for cGMP and regulatory compliance when manufacturing peptide products for clinical use.

Learning Objectives:

• Learn from experts in the field of peptide drug development, discovery and chemical synthesis.
• Understand what factors influence target selection.
• Learn how to overcome solid phase peptide synthesis challenges such as increasing purity and yield of the target product, and reducing impurities and side-products.
• Learn how to optimize your peptide synthesis with a focus on scale-up and manufacture. 

How can we improve the purification process? This webinar will look at current techniques in purification, including Peptide Easy-Clean (PEC) Technology.
Ask the experts! A great opportunity to ask your questions to our panel of experts. Register today. 
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Speakers:
Dr. Christian Bartling, Post-Doctoral Researcher (Strømgaard Group),  University of Copenhagen
Dr. Céline Douat, Scientific Coworker (Huc Group),  LMU Munich
Dr. Colin Dunsmore, Team Leader, Almac Sciences
Dr. Robert Zitterbart, Co-founder & Head of R&D, Belyntic GmbH 
Dr. Lukasz Frankiewicz, Senior Product Specialist (EMEA), Gyros Protein Technologies

​Presentation Overview
 Target Identification

• How do investigators identify lead targets for investigation as it relates to their research?
• What challenges to researchers face when selecting appropriate targets?
• What about peptides as research tools, how are peptides used in this respect (Alanine scanning, chemokines, histones etc.)

 Solid Phase Peptide Synthesis

• Synthesis design and planning
• Synthesis challenges
• Analysis: Identifying target product and impurities/side-products
• Process Development: How to optimize a synthesis?
• How does synthetic methodology affect scale-up and manufacture?

 Cleavage and Purification

• Challenges faced at this stage.
• Peptide Easy Clean Technology and LC purification.

 Audience Questions

The Kay lab at the University of Utah is focused on D-peptide inhibitor development, which requires the chemical synthesis of mirror-image protein targets. This webinar will describe the use of recently developed chemical and computational tools to accelerate chemical protein synthesis of large proteins. Specific topics will include recently developed next-generation “helping hand” traceless linkers to improve peptide solubility, the use of traceless templating to accelerate ligations, and our automated ligator program (Aligator) for prediction of the optimal synthetic routes. 

LEARNING OBJECTIVES: 

• “Helping hand” traceless linkers are a valuable tool for solubilizing difficult peptide segments. 
• Templated ligations greatly accelerate ligations and can rescue otherwise suboptimal ligation junctions. 
• Computational simulation of potential chemical protein synthesis routes can be used to predict optimal synthesis strategies. 

Who should attend: 

• Scientist, Senior Scientists, Technical Leaders or researchers with an interest in peptide or protein chemistry. 
• PhD Candidates, Post-Doctoral Researchers 
• Researchers involved in Peptide Therapeutics or Peptide Synthesis. 

​DATE: 

• 2020.11.14 2am - 3am KST (Friday, November 13th, 2020. 12pm – 1pm EST)  

​Speaker:  MICHAEL S. KAY PROFESSOR OF BIOCHEMISTRY