Peptide Therapeutics: Discovery, Development and Manufacture
2021년 3월 4일 03:00AM (한국시간)
Wednesday 3rd March 2021 | 16:00 GMT (UTC+0) | 11:00 ET
Ask the experts! A great opportunity to ask your questions to our panel of experts. Register today.
Dr. Christian Bartling, Post-Doctoral Researcher (Strømgaard Group), University of Copenhagen
Dr. Céline Douat, Scientific Coworker (Huc Group), LMU Munich
Dr. Colin Dunsmore, Team Leader, Almac Sciences
Dr. Robert Zitterbart, Co-founder & Head of R&D, Belyntic GmbH
Dr. Lukasz Frankiewicz, Senior Product Specialist (EMEA), Gyros Protein Technologies
[Webinar] Sequence-Specific “Peptoids” for Antifouling, Antibacterial and Self-Assembly Applications
Presented by K.H Aaron Lau, PhD, Senior Lecturer (Associate Professor) at the Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, Scotland, United Kingdom
Analogous to peptides, non-natural poly(N-substituted glycine) “peptoids” exhibit self-assembly properties and bioactivity that are encoded by the ordering of monomer residues into specific sequences along their polymer backbone. Peptoids differ from peptides in the shift of the sidechain attachment to the backbone amide-nitrogen atoms. They are resistant to protease degradation and have simplified intermolecular interactions.
In this webinar, sponsored in partnership with Xtalks Dr. K.H Aron Lau highlights recent efforts in exploring solid-phase synthesized peptoids for applications beyond their conventional use in combinatorial drug discovery. This includes a look into how peptoids can be tailored to form antifouling peptoid polymer brushes and antibacterial surfaces, and also self-assembly. The webinar concludes with a presentation of the finer points of peptoid synthesis using Prelude® X peptide synthesizer. Dr Lau saw the benefits of using this instrument for the peptoid project. “The flexibility of Prelude X enabled automation of different chemistries, and it was relatively straightforward to adapt it to the submonomer protocol for peptoid synthesis. And the possibility of parallel synthesis of different sequences and reliable control of temperature is very useful.”