Solid Phase Peptide Synthesis: Design, Side-Reactions and Manufacture
11 AM EST Wed 21, April 2021 (한국시간 2021년 4월22일 목요일 오전 0시)
Peptide-based therapeutics are increasingly being seen as the future for many drug development programs, and these compounds can be found in many clinical therapeutic areas such as cancer vaccines, personalized medicines, and treatments for metabolic and cardiovascular diseases. These ground-breaking drug discoveries usually begin with the solid phase peptide synthesis (SPPS) of a target sequence. With the increasing chemical complexity of these peptides how can you maximize the likelihood of success when developing a protocol to automate synthesis for a new peptide sequence? How can the risk of side-reactions be minimized? And what challenges face the chemist when moving to manufacture? This webinar will cover the main areas of SPPS theory and synthesis design, focusing on first principles such as sequence analysis and synthetic methodology. There will also be a focus on side reactions that occur during SPPS and what strategies can be employed to reduce or eliminate these from occurring. We also discuss features of peptide synthesizers that are critical for cGMP and regulatory compliance when manufacturing peptide products for clinical use.
Understand how to design a solid phase peptide synthesis protocol and learn how to analyze a sequence and create a synthetic methodology based on first principles.
How to identify unwanted side products that can form during SPPS and learn how to implement proactive measures to reduce the risk of side reactions occurring.
Understand which factors are important for the manufacture of clinical peptides under cGMP conditions.