Three reaction vessels
Typical cycle times are under 40 minutes per coupling. Three reaction vessels let you synthesize up to three completely different peptides sequentially without operator attention. PS3 will perform up to 45 couplings automatically, without reloading or user intervention. Set it up to run overnight or over a weekend, for maximum productivity.
Standard or custom program
“Plug’n play” simplicity allows you to load vials in sequence and indicate what start and stop positions. Specify standard or custom program for each coupling, and push "RUN."
The zero-dead-volume fluid valve system has all PTFE wetted surfaces and just one moving part. A self-diagnostic program and multiple sensors ensure proper performance while a printer provides a permanent record of each synthesis. Fluid transfer and mixing are accomplished under inert atmospheres of nitrogen or argon.
Supports Fmoc and t-Boc chemistries
PS3 allows you to use a variety of coupling techniques: Fmoc-N-carboxyanhydride and Fmoc-acid fluoride chemistries can be performed without instrument modification. Different chemistries can be mixed in one synthesis.
PS3 can also be used with either Fmoc or t-Boc protected amino acids. Pre-packaged reagents are available for 0.1 and 0.5 mmol synthesis scales. Coupling programs can be customized for special needs.
Number of reaction vessels
Synthesis scale range
Reaction vessel volume
Number of solvent positions/sizes
Number of amino acid positions
Fluid measurement technique
Fluid transfer method
3, used sequentially
0.005 – 1.5 mmol (at 2x excess)
Glass, 30mL, 75mL
2 x 4 L primary solvent
1 x 1 L deprotectant
1 x 1 L base
45 amino acid vials, 5 mL capacity
10 mL, 120 mL and 400 mL bottles
Pre-packaged vials available
0.4 mmol, 1.0 mmol scales
Fmoc, t-Boc, organic, others
HBTU, HATU, HCTU, TBTU, PyBOP, others
Timed delivery, conformed with optical sensors
Positive pressure with nitrogen
One 20 L container
On-board CPU, LCD display and keyboard
Preset and user programmable coupling conditions
Manual operation, cleaning procedures
Direct output to external printer (printer included on 115 V units only)
115 V/60 Hz or 230 V/50 Hz
32" x 21" x 19.5" (81 cm x 53 cm x 49 cm)
Approximately 51 lbs. (23 kg)
One year, parts and labor.